Beef Research

Celmanax® Research

Effects of Celmanax Liquid on Survival of Beef Calves with Acute mycotoxin Poisoning and Jejunal Hemorrhage Syndrome and on the Cytotoxicity of Feed Extracts To Enterocytes in Vitro**

Conclusion: From digesta and tissues of beef cattle dying from JHS, both O157:H7 and non-O157:H7 serovars of Shigatoxin producing E. coli were isolated. No pathogenic Salmonella, Listeria or Clostridia were found. Several mycotoxigenic fungi, including Aspergillus fumigatus, Penicillium roqueforti and several Fusarium species were identified in forages from the affected feedlots. It appears that the development of JHS requires the dual insults of a pathogenic bacteria and a mycotoxin challenge. These challenges are not limited to Aspergillus fumigatus and Clostridium perfringens Type A as previously thought. Celmanax, at 0.1%, was able to completely eliminate the cytotoxic effects of extracts from these forages in vitro. A single dose of 400 mL of Celmanax Liquid was able to reverse the course of disease in 69% of calves with advanced and progressive mycotoxicosis and presumptive JHS.
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Effect of Celmanax® Liquid on the Attachment of Cryptosporidium Sporozoites to Bovine Epithelial Cells In-Vitro
RB38
Introduction: Celmanax is a yeast culture product, which has been modified or improved to express more of the metabolites associated with the yeast culture fermentation process. One of the metabolites associated with this production process is Galactosamine. N-acetyl galactosamine has demonstrated an ability to interfere with Cryptosporidium spp ability to attach to intestinal epithilium1. Inhibition of Cryptosporidium sporozoites to adhere and penetrate host cells in the presence of sugars and complex carbohydrates has been reported2. In this study effect of Celmanax on attachment of Cryptosporidium parvum sporozoites to bovine cells is investigated.
Conclusions: The results from this study suggest that Celmanax significantly inhibits the binding of C. parvum sporozoites to bovine epithelial cells in-vitro in a dose-dependent manner.
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