Celmanax® Research
Dairy Research
The Effect of Yeast Culture (YC), Mannan Oligiosaccharide (MOS) and Enzymatically Hydrolyzed Yeast (EHY) on Production Performance in Dairy Cattle
Conclusion: Cows supplemented with A-Max® and Celmanax produced more milk, FCM and ECM than non-supplemented cows. Milk protein percentage was higher for cows supplemented with Celmanax compared to DV/MOS. Protein yields were higher for A-Max and Celmanax supplemented cows compared to control and DV/MOS. Somatic cell count was lower for cows supplemented with products containing MOS; however, there was a significant Pen (trt) effect.
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The Effect of Yeast Culture (YC) and Mannan Oligiosaccharide (MOS) and Enzymatically Hydrolyzed Yeast (EHY) on Production Performance in Dairy Cattle
Conclusion: Cows supplemented with Celmanax produced more milk, FCM, and ECM than non-supplemented cows. Milk protein percentage was higher for cows supplemented with Celmanax compared to DV/MOS. Protein yields were higher for Celmanax supplemented cows compared to Control and DV/MOS. Somatic cell count was lower for cows supplemented with Celmanax and DV/MOS; however, there was a significant Pen (trt) effect.
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The Effect of Enzymatically Hydrolyzed Yeast (EHY, Celmanax) on Production Performance in Dairy Cattle
Conclusion: Cows supplemented with Celmanax produced more milk, FCM, ECM, and higher milk protein percentage than non-supplemented cows. Fat, protein, and SNF yields were higher for Celmanax supplemented cows compared to Control. Somatic cell count was lower for cows supplemented with Celmanax.
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The Effect of Enzymatically Hydrolyzed Yeast (EHY, Celmanax) on Production Performance in Dairy Cattle
Conclusion: Cows (multiparous, 1-84 DIM) supplemented with Celmanax produced 1.8 kg more milk than non-supplemented cows, however, this was not statistically significant (P>.05). Milk composition and yield was not affected by Celmanax supplementation. Clinical mastitis cases and cows with somatic cell count > 400,000 was lower for cows supplemented with Celmanax compared to control.
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Celmanax Liquid in Dairy Calf Milk Replacers
Conclusion: Adding Celmanax Liquid provided a significant benefit in this farm by improving weight gain, feed efficiency, and reducing medical costs.
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Celmanax Liquid in Dairy Calf Milk Replacers
Conclusion: Adding Celmanax Liquid provided a significant benefit to this trial by improving weight gain, feed/gain, and reducing medical costs.
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Effect of Celmanax Liquid on Crypto Oocyst Shedding, Fecal, and Dehydration Scores in Infected Dairy Calves: a Field Demonstration
Conclusion: Calves supplemented with Celmanax Liquid shed 3 fold less oocysts and had significantly improved fecal and dehydration scores.
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Effects of Celmanax Liquid on Jejunal Hemorrhage Syndrome, E. Coli Adhesion, and Mycotoxin Induced Cytotoxicity
Conclusion: From samples of jejunum and digesta from 13 cows dying from JHS, O157:H7 and non- O157:H7 Shiga toxin producing serovars of E. coli were isolated, along with several mycotoxigenic fungi of the Penicillium, Aspergillus, Fusarium and Tricothecene families. In a dose dependent manner, Celmanax Liquid significantly reduced the adherence of E. coli O157:H7 to explants of healthy jejunal tissue. Lastly, Celmanax Liquid eliminated the cytotoxic effects of both purified mycotoxins and extracts from moldy forages when added to a culture of jejunal cells. Celmanax Liquid may be able to play a significant role in reducing the effects of some pathogenic bacteria, mycotoxins and the incidence of JHS.
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A Comparison of Celmanax, Dried With or Without a Carrier, on Production Performance in Lactating Dairy Cows
Conclusion: These results demonstrate that the performance of Celmanax SCP is equivalent to that of Celmanax Dry in lactating dairy cows.
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Effect of Celmanax SCP in Dairy Calves
Conclusion: Calves supplemented with Celmanax SCP showed numerical improvement in weight gain.
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Effect of Celmanax SCP on Calf Performance When Fed in the Milk Replacer and Grower Phase
Conclusion: Calves supplemented with Celmanax SCP showed numerical improvement in weight gain and feed efficiency.
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Beef Research
Effects of Celmanax Liquid on Survival of Beef Calves with Acute mycotoxin Poisoning and Jejunal Hemorrhage Syndrome and on the Cytotoxicity of Feed Extracts To Enterocytes in Vitro**
Introduction: Jejunal Hemorrhage Syndrome (JHS, also known as Hemorrhagic Bowel Syndrome or HBS) is a hemorrhagic disease of beef and dairy cattle. It is typically characterized by sudden death which, upon investigation, is found to be caused by massive hemorrhaging of the jejunum and blockage of the intestine with the resulting blood clot. Early work on this disease complex identified two associated factors, moldy feed containing Aspergillus fumigatus and the bacterial pathogen Clostridium perfringens Type A. More recent work from Dr. Baines’ lab expanded the scope of potential causative agents of JHS in dairy cattle to a wider range of mycotoxigenic fungi and to Shigatoxin producing E. coli (also known as STEC. See Vi-COR® Dairy Research Bulletin D-68). STEC is one of the leading causes of food borne pathogen outbreaks in humans, resulting in hemorrhagic colitis and hemolytic uremic syndrome. Cattle are the principal reservoir of these pathogens.
Conclusion: From digesta and tissues of beef cattle dying from JHS, both O157:H7 and non-O157:H7 serovars of Shigatoxin producing E. coli were isolated. No pathogenic Salmonella, Listeria or Clostridia were found. Several mycotoxigenic fungi, including Aspergillus fumigatus, Penicillium roqueforti and several Fusarium species were identified in forages from the affected feedlots. It appears that the development of JHS requires the dual insults of a pathogenic bacteria and a mycotoxin challenge. These challenges are not limited to Aspergillus fumigatus and Clostridium perfringens Type A as previously thought. Celmanax, at 0.1%, was able to completely eliminate the cytotoxic effects of extracts from these forages in vitro. A single dose of 400 mL of Celmanax Liquid was able to reverse the course of disease in 69% of calves with advanced and progressive mycotoxicosis and presumptive JHS.
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Effect of Celmanax Liquid on the Attachment of Cryptosporidium Sporozoites to Bovine Epithelial Cells In-Vitro
Introduction: Celmanax is a yeast culture product, which has been modified or improved to express more of the metabolites associated with the yeast culture fermentation process. One of the metabolites associated with this production process is Galactosamine. N-acetyl galactosamine has demonstrated an ability to interfere with Cryptosporidium spp ability to attach to intestinal epithilium1. Inhibition of Cryptosporidium sporozoites to adhere and penetrate host cells in the presence of sugars and complex carbohydrates has been reported2. In this study effect of Celmanax on attachment of Cryptosporidium parvum sporozoites to bovine cells is investigated.
Conclusion: The results from this study suggest that Celmanax significantly inhibits the binding of C. parvum sporozoites to bovine epithelial cells in-vitro in a dose-dependent manner.
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Poultry Research
Effect of Celmanax® on nutrient digestibility and production performance in broilers fed diets with normal and low energy and different protein sources.
Introduction: Celmanax is a yeast-derived supplement capable of improving growth performance in broilers. Alternate protein sources are continuously being investigated to supplement diets deficient in energy. The effect of Celmanax under these conditions is tested here.
Conclusions: The inclusion of Celmanax in low energy diets for broiler chickens formulated with different protein sources improved daily weight gain and feed efficiency by 25 and 27%, respectively. The increased performance in broiler chickens fed low energy density diets with Celmanax, as compared to the birds fed a low energy diet with no Celmanax, may be explained by the higher nutrient digestibility.
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Effect of supplementation of Celmanax® and a DFM product on growth performance, ileal digestibility, and intestinal development in broiler diets in young chicks.
Introduction: Both prebiotics as well as probiotics are used to improve the production performance in broilers. In this study, the effect of a yeast-based prebiotic (Celmanax) and a commercial probiotic, either individually or in combination, is studied.
Conclusions: Chickens supplemented with Celmanax had increased weight gain and feed efficiency as compared to the control group. Ileal digestibility of dry matter, ash, nitrogen, and energy was increased in chickens supplemented with Celmanax. Additionally, Celmanax increased crypt depth and width. The addition of a DFM to the diet improved weight gain and carcass yield, but not digestibility or intestinal villi development.
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Effect of Celmanax® supplementatation on performance and in protecting broilers against a moderate coccidiosis challenge.
Introduction: Celmanax is an enzymatically hydrolyzed yeast and yeast culture manufactured as a combined supplement. Celmanax contains complex sugars like galactosamine, mannose, and mannan oligosaccharide (MOS). Some of these sugars play an important role in preventing infections by some pathogenic bacteria and parasites. Ability of Celmanax to agglutinate E. coli and Salmonella spp has been shown before. In this study, effect of Celmanax on Eimeria challenged broiler chicks was assessed.
Conclusions: Overall, Celmanax appeared to have performance improving properties when fed to non-challenged broilers, and showed significant efficacy against E. tenella but not against E. maxima and E. acervulina challenge. This work was presented at the ADSA-ASAS Joint Annual Meeting, 2008 and published in the Journal of Animal Science volume 86,
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Effect of Celmanax® supplementation in broiler diets on production performance of broilers.
Introduction: Celmanax is an enzymatically hydrolyzed yeast and yeast culture manufactured as a combined supplement. It contains complex sugars such as beta glucans, galactosamine, mannose, and mannan oligosaccharide (MOS). Yeast culture and MOS containing products play an important role in modulating gut health, gut morphology, and immune function in the animal resulting in improved production performance.
Conclusions: Celmanax provided a significant benefit in this research trial by significantly improving weight gain and the production index.
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Effect of supplementation of Celmanax®, antibiotics, and two lysine levels in broiler diets.
Introduction: Broiler health and growth performance is improved with the use of antibiotics, but as more and more countries are moving away from antibiotics, the need to look for alternatives is urgent. Here, supplementation of a yeast-based prebiotic (Celmanax) is compared to that of antibiotics.
Conclusions: Celmanax provided a significant benefit in this research trial by improving feed intake, weight gain, feed efficiency, carcass weights, and carcass yields. Broiler diets with Celmanax provided higher nutrient utilization and higher retention of nutrients.
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Effect of Celmanax® liquid on performance, immune function, and health of broilers challenged with E. coli O78
Introduction: Celmanax Liquid is an enzymatically hydrolyzed yeast and yeast culture manufactured as a combined supplement. Celmanax Liquid contains complex sugars such as beta glucans, galactosamine, mannose, and mannan oligosaccharide (MOS). Yeast culture and MOS containing products play an important role in improving overall intestinal well being and in modulating immune function in the animal. The ability of Celmanax to agglutinate E. coli and Salmonella spp has been shown before. In this study, the effect of Celmanax on E. coli challenged broiler chicks was assessed.
Conclusions: Supplementation of Celmanax Liquid significantly improved performance resulting in
253 g heavier birds at the end of the trial compared to control birds. Additionally, by modulating the cellular immunity, Celmanax Liquid reduced morbidity and mortality in birds infected with E. coli compared to infected birds.
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Effect of Celmanax® supplementation in aflatoxin-contaminated starter diets on broiler performance
Introduction:Celmanax® is an enzymatically hydrolyzed yeast and yeast culture manufactured as a combined supplement. Celmanax contains many yeast derived metabolites such as beta glucans, mannans and galactosamine. These complex sugars play an important role in modulating gut health and improving broiler production. Yeast derived mycotoxin binders have shown some success in both in vitro and in vivo systems. In previous studies Celmanax has shown mycotoxin binding abilities and an elimination of the cytotoxic effects of mycotoxins in vitro as well as some immune modulating functions. Consequently, a study was undertaken to evaluate if Celmanax could mitigate an aflatoxin induced challenge in broilers.
Conclusions: Overall, the supplementation of Celmanax to aflatoxin-contaminated broiler starter diets numerically improved weight gain and decreased feed conversion compared to the control. Thus, Celmanax supplemented in the diet is able to improve the performance of broilers when faced with an aflatoxin challenge.
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Effect of Celmanax® supplementation on the performance of broilers vaccinated with Coccivac-B or fed a Coccidiostat
Introduction: In a typical broiler operation, one of two methods is used to control coccidiosis: 1) vaccinate all chicks at hatching, or 2) supplement the diet with a coccidiostat. Previous studies have shown supplementation of Celmanax® to be successful in improving the performance of broilers not treated for coccidiosis,. It will be beneficial if a feed additive could improve the overall performance of broilers under the current coccidiosis control regimens. With this aim in mind, the current study was undertaken.
Conclusions: The supplementation of Celmanax SCP in broiler diets effectively enhanced bird performance by significantly improving weight gain, lowering feed conversion ratio and improving bird uniformity at slaughter under the current field practices for control of coccidiosis.
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Swine Research
Effect of Celmanax in Pig Diets in Response to an Immune Challenge
Introduction: Celmanax is an improved yeast culture product expressing more of the metabolites associated with the yeast culture fermentation process. Celmanax contains many complex carbohydrates like Mannan Oligosaccharides (MOS) and beta-glucans. Yeast culture and MOS containing products play an important role in improving overall intestinal well being and in modulating immune function in the animal.
Conclusion: Compared to the LPS-challenged control pigs, Celmanax supplemented pigs had a lower rectal temperature and respiratory rate during the first 4 hours after injection, which implied that Celmanax improves some aspect of the immune function and provides some benefit for weaned pigs during an immune challenge.
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